Six teenagers are in hospital with critical injuries after an allegedly stolen car crashed into an embankment after a suspected high-speed joyride in Melbourne's north.

The allegedly stolen Haval crashed and rolled near the entrance of the Hume Freeway on O'Herns Road in Epping about 1.30am.

All six occupants of the car were rushed to hospital with serious injuries, including one person who was airlifted due to the severity of their injuries.

The car was first spotted speeding by a patrol car near Church Street in Whittlesea about 1am today.

After losing sight of the car, police AirWing located the SUV about 20 minutes later, where it was allegedly speeding near Plenty Road in South Morang.

Stop sticks were successfully deployed on Bellevue Boulevard.

Police AirWing continued trailing the Haval, which allegedly continued speeding through Epping before it crashed.

Police were not pursuing the Haval before it crashed.

The occupants include three 17-year-old boys from the Whittlesea area, two 16-year-old boys from the Hume area and a 19-year-old Seymour woman.

They are all under police guard in hospital.

The Haval was allegedly stolen during an aggravated burglary on a home on Starboard Drive in Doreen early on Tuesday morning.

Both the on-ramp and the inbound exit of the Hume Highway at O'Herns Road remain closed as of 12pm.

O'Herns Road is also closed between Gateway Boulevard and the freeway.

Motorists have been warned of delays of more than 45 minutes.

Investigations remain ongoing. 

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